Senior Research Scientist - Modelling & Simulations

AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

We are looking for an experienced Senior Research Scientist with expertise in Modeling and Simulations who can design, develop, and leverage Systems Pharmacology and Pharmacometric approaches that will help accelerate drug development of antibody therapeutics across a variety of therapeutic areas and modalities. In this role, you will work within a team of modelers and bioinformaticians, and collaborate with diverse project teams consisting of biologists, protein engineers, pharmacologists, clinicians, and others to help guide program development. Your modeling and simulation approaches will integrate data from internal studies and external literature, and will support the design and interpretation of in vivo pharmacology studies as well as clinical trials.

How you might spend your days:

• Collaborating with scientists across Discovery and Development to develop and execute modeling strategies that contribute to project team discussions and guide therapeutic and dose selection decisions 
• Developing and implementing Quantitative Systems Pharmacology (QSP) and PK/PD modeling strategies to predict the behavior of therapeutics in disease-relevant systems and provide mechanistic understanding of the PK and PD profile
• Partnering with the Pharmacology and Pharmacokinetics teams to support study design and analysis of data from in vivo studies
• Collaborating with Clinical Pharmacology and Biostatistics experts to integrate modeling and simulation strategies to answer questions around clinical trial design and dose selection
• Performing sensitivity analysis and hypothesis testing in order to identify key design parameters of interest for antibody molecules
• Presenting findings and results in a concise manner to a diverse audience
• Acting as a subject matter expert in projects where modeling and simulations input is required

We’d love to hear from you if: 

• You have a PhD in Mathematics, Pharmaceutical Sciences, Computational Biology, or a related field, and a minimum of 5-8 years of relevant experience, including experience in an industry environment 
• You have hands-on experience in Quantitative Pharmacology and/or Pharmacometric approaches with a focus on QSP and PK/PD modeling in pre-clinical or early clinical development
• You have excellent understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including using numerical methods and parameter estimation/optimization
• You have hands-on experience using mathematical modeling software (e.g., Matlab, Simbiology, NONMEM, Julia, Monolix), as well as data analysis and visualization software (e.g., R, Python)
• You have good understanding of pharmacokinetic and pharmacodynamic principles for antibody and small molecule therapeutics 
• You have an ability to learn new areas of biological sciences and integrate the knowledge and data to develop QSP models
• You have experience supporting and working with cross-functional teams in a dynamic environment
• You have a demonstrated ability to find creative and functional solutions to complicated problems
• You have the ability to express complex ideas in understandable ways, and to communicate effectively with people from different fields
• You have excellent documentation skills with impeccable attention to detail

What we offer:

AbCellera’s hiring range for this role is CAD $114,000 - $142,600 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution. 

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize teams and social groups to build community and connections across AbCellera.

About AbCellera:

AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

And it all starts with our team. We’ve built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.

We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success. 

To apply:

Please submit your application through our website and refer to Job ID 23268 in your cover letter. We apologize in advance, but we receive a large volume of applications and are only able to contact those who are selected for an interview.

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